Do GnRH agonists cause osteoporosis?
The intended therapeutic effect of gonadotropin-releasing hormone (GnRH) agonists is hypogonadism, a major cause of acquired osteoporosis in men. Consistent with this observation, GnRH agonists increase bone turnover and decrease bone mineral density, a surrogate for fracture risk.
What are the side effects of gonadotropin-releasing hormone GnRH agonists?
Common side effects of the GnRH agonists and antagonists include symptoms of hypogonadism such as hot flashes, gynecomastia, fatigue, weight gain, fluid retention, erectile dysfunction and decreased libido. Long term therapy can result in metabolic abnormalities, weight gain, worsening of diabetes and osteoporosis.
How does androgen deprivation therapy cause osteoporosis?
Osteoporosis is an important complication of androgen deprivation therapy (ADT). ADT by either orchiectomy or treatment with a gonadotropin-releasing hormone agonist decreases bone mineral density and increases fracture risk.
What is the flare effect GnRH agonists?
Peptide GnRH agonists are administered subcutaneously, intranasally, or intramuscularly. An initial agonistic action (i.e., flare effect) is associated with an increase in the circulating levels of LH and FSH.
Does GnRH analogues cause osteoporosis?
The intended therapeutic effect of gonadotropin-releasing-hormone (GnRH) agonists is hypogonadism, which is a leading cause of osteoporosis in men. Observations are consistent with this effect: GnRH agonists decrease bone mineral density and increase fracture risk in men with prostate cancer.
Does Lupron cause loss of bone density?
The induced hypoestrogenic state also results in a loss in bone density over the course of treatment, some of which may not be reversible. Clinical studies show that concurrent hormonal therapy with norethindrone acetate 5 mg daily is effective in reducing loss of bone mineral density that occurs with LUPRON.
What could happen to the body if there is too much gonadotropin-releasing hormone?
What happens if GnRH levels are too high? An overproduction of GnRH is rare. Elevated levels may increase your risk of pituitary adenomas. These noncancerous (benign) tumors can cause your body to make too much follicle-stimulating hormone and luteinizing hormone.
What would be the effect of a GnRH antagonist?
A substance that blocks the pituitary gland from making hormones called follicle-stimulating hormone (FSH) and luteinizing hormone (LH). In men, this causes the testicles to stop making testosterone. In women, this causes the ovaries to stop making estrogen and progesterone.
Does Zoladex cause osteoporosis?
Zoladex can decrease bone mineral density, which may increase your risk of developing osteoporosis. This risk may be greater if you smoke, drink alcohol frequently, have a family history of osteoporosis, or use certain drugs such as seizure medications or steroids.
What is the difference between GnRH agonist and GnRH antagonist?
GnRH agonist acts like GnRH. When GnRH agonist is first given, it causes the pituitary to become more active. However, after a while, the pituitary stops responding to the constant GnRH agonist. By contrast, the GnRH antagonist directly blocks the pituitary from responding to GnRH.
Is Lupron a GnRH?
Leuprolide injection (Lupron Depot) is also used with other medication to treat anemia (a lower than normal number of red blood cells) caused by uterine fibroids (noncancerous growths in the uterus). Leuprolide injection is in a class of medications called gonadotropin-releasing hormone (GnRH) agonists.
Is osteoporosis a disease?
Osteoporosis is a bone disease that develops when bone mineral density and bone mass decreases, or when the quality or structure of bone changes. This can lead to a decrease in bone strength that can increase the risk of fractures (broken bones).
Can Lupron cause bone pain?
Patients receiving leuprolide for advanced prostate cancer: At first, some of your symptoms might get worse for a short time or you might have new symptoms. You might have bone pain, back pain, a tingling or numbness in the body, blood in the urine, or trouble urinating.
Does Lupron cause joint pain?
The FDA currently has over 25,000 adverse event reports for Lupron products including more than 1500 deaths. Reactions include suicidal thoughts, stroke, muscle atrophy and debilitating bone and joint pain.
Which hormone dramatically affects physical appearance?
Thyroxine is the hormone that affects our physical appearance. It denotes regular solution and denotes actual changes in the allocation of resources affect the physical appearance.
What effect would increasing the GnRH levels have at first?
What effect would increasing the GnRH levels have at first? It would cause an increase in the secretion of LH and FSH. What does it mean when the GnRH receptors are downregulated? The increased levels of GnRH decreases the number of receptors.
What is the difference between GnRH agonist and antagonist?
When do you give GnRH agonist?
Treatment with a GnRH agonist before surgery may reduce the likelihood of ovarian endometriomas recurring [7], but the evidence is controversial [8]. Six months of GnRH agonist therapy immediately following surgery reduces the rate of symptom recurrence [9], and increases the length of time before symptoms recur [1].
Can Zoladex cause bone pain?
Worsening of cancer symptoms, such as bone pain, may occur during the first few weeks after Zoladex is implanted.