What is doxorubicin HCL used for?
A drug that comes from the bacterium Streptomyces peucetius and is used alone or with other drugs to treat many types of cancer, including leukemia, lymphoma, neuroblastoma, sarcoma, Wilms tumor, and certain cancers of the lung, breast, stomach, ovary, thyroid, and bladder.
Is doxorubicin the strongest chemo?
Official answer. Doxorubicin is considered one of the strongest chemotherapy drugs for breast cancer ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers, not just breast cancer.
How effective is doxorubicin for breast cancer?
Resistance to chemotherapeutic drugs can cause treatment failure in over 90% of patients with metastatic cancer [2]. Doxorubicin (DXR) is part of the anthracycline family and is currently the most effective chemotherapeutic drug used to treat breast cancer [3, 4].
What kind of chemo is doxorubicin?
Doxorubicin is a type of chemotherapy drug called an anthracycline. It slows or stops the growth of cancer cells by blocking an enzyme called topo isomerase 2. Cancer cells need this enzyme to divide and grow. You might have doxorubicin in combination with other chemotherapy drugs.
What cancers use doxorubicin treat?
Doxorubicin is used in combination with other medications to treat certain types of bladder, breast, lung, stomach, and ovarian cancer; Hodgkin’s lymphoma (Hodgkin’s disease) and non-Hodgkin’s lymphoma (cancer that begins in the cells of the immune system); and certain types of leukemia (cancer of the white blood cells …
What types of cancers does doxorubicin treat?
Doxorubicin hydrochloride is approved to be used alone or with other drugs to treat:
- Acute lymphoblastic leukemia (ALL).
- Acute myeloid leukemia (AML).
- Breast cancer.
- Gastric (stomach) cancer that is metastatic.
- Hodgkin lymphoma.
- Neuroblastoma that is metastatic.
- Non-Hodgkin lymphoma.
Which is the most serious side effect of doxorubicin?
This medicine may cause irreversible heart muscle damage, leading to heart failure. This is more likely to occur if you have other heart problems, have had or currently receiving radiation therapy to your chest, or have received other cancer medicines.
Will I lose my hair with doxorubicin?
Your hair may become thin, brittle, or may fall out. This typically begins two to three weeks after treatment starts. This hair loss can be all body hair, including pubic, underarm, legs/arms, eyelashes, and nose hairs.
How many cycles of doxorubicin can you have?
Each cycle of treatment lasts 21 days (3 weeks). You usually have up to 6 cycles in total.
What is the most common side effect of doxorubicin?
Commonly reported side effects of doxorubicin include: severe nausea and vomiting, nausea and vomiting, and alopecia.
Do you lose your hair with doxorubicin?
How do you feel after doxorubicin?
The following side effects are common (occurring in greater than 30%) for patients taking Doxorubicin:
- Pain along the site where the medication was given.
- Nausea or vomiting (You will be pretreated for this side effect)Later Side Effects: (within two weeks after treatment begins)
Why does doxorubicin have a lifetime limit?
The dose is limited to reduce the risk of toxic side effects, such as heart toxicity (cardiotoxicity).
What is doxorubicin hydrochloride injection?
Doxorubicin Hydrochloride Injection is indicated as a component of multi-agent adjuvant chemotherapy for treatment of women with axillary lymph node involvement following resection of primary breast cancer. Doxorubicin Hydrochloride Injection is indicated for the treatment of
Is doxorubicin hydrochloride liposome toxic?
Doxorubicin hydrochloride liposome injection is a cytotoxic drug. Follow applicable special handling and disposal procedures.1 If doxorubicin hydrochloride liposome injection comes into contact with skin or mucosa, immediately wash thoroughly with soap and water.
What is the molecular structure of doxorubicin?
Doxorubicin Liposomal Description. The molecular structure is: Doxorubicin hydrochloride liposome injection is a sterile, translucent, red liposomal dispersion in 10-mL or 30-mL glass, single-dose vials. Each vial contains 20 mg or 50 mg doxorubicin HCl at a concentration of 2 mg/mL and a pH of 6.5.
What is the pathophysiology of cardiotoxicity from doxorubicin?
Cardiotoxicity is a known risk of anthracycline treatment. Anthracycline-induced cardiotoxicity may be manifested by early (or acute) or late (delayed) events. Early cardiotoxicity of Doxorubicin consists mainly of sinus tachycardia and/or electrocardiogram (ECG) abnormalities such as non-specific ST-T wave changes.