What does KEGG pathway analysis tell you?
KEGG is a database resource for understanding high-level functions and utilities of the biological system, such as the cell, the organism and the ecosystem, from molecular-level information, especially large-scale molecular datasets generated by genome sequencing and other high-throughput experimental technologies.
What is a KEGG pathway enrichment?
KEGG mapping is the process to map molecular objects (genes, proteins, small molecules, etc.) to molecular interaction/reaction/relation networks (KEGG pathway maps, BRITE hierarchies and KEGG modules). It is not simply an enrichment process; rather it is a set operation to generate a new set.
How do you analyze a KEGG pathway?
You can use the KEGG database directly @ https://www.genome.jp/kegg/. Click on the KEGG mapping displayed on the left side, then click on the search pathway, and paste the gene ID in the displayed box. finally, execute to get the results of your analysis. It is user friendly and works perfectly.
What is KEGG Orthology?
The KO (KEGG Orthology) database is a database of molecular functions represented in terms of functional orthologs. A functional ortholog is manually defined in the context of KEGG molecular networks, namely, KEGG pathway maps, BRITE hierarchies and KEGG modules.
What is KEGG pathway used for?
KEGG is utilized for bioinformatics research and education, including data analysis in genomics, metagenomics, metabolomics and other omics studies, modeling and simulation in systems biology, and translational research in drug development.
Why is KEGG pathway used?
The main objective of KEGG has been to establish links from collective sets of genes in the genome to high-level functions of the cell and the organism.
How are KEGG pathways created?
The KEGG PATHWAY database has been and will continue to be the main database in KEGG. It consists of manually drawn reference pathway maps together with organism-specific pathway maps that are computationally generated by matching KO assignments in the genome with reference pathway maps.
How many KEGG pathways are there?
KEGG contains 179 module pathways versus 1,846 base pathways in MetaCyc; KEGG contains 237 map pathways versus 296 super pathways in MetaCyc. KEGG pathways contain 3.3 times as many reactions on average as do MetaCyc pathways, and the databases employ different conceptualizations of metabolic pathways.
How is KEGG used?