Is spindle cell carcinoma serious?
Spindle cell carcinoma (SpCC) is a very rare tumor with a poor prognosis. The literature on the treatment and disease progression is still very limited, and there is a need for publishing long-term follow-up of such patients.
What is spindle cell carcinoma?
Spindle cell carcinoma represents a rare variant of squamous cell carcinoma, characterized by spindled tumor cells that simulate a sarcoma but are epithelial in nature. The tumor can arise anywhere within the upper aerodigestive tract, with a predilection for the larynx and oral cavity.
Is spindle cell squamous cell carcinoma curable?
It is an aggressive variant of squamous cell carcinoma. The usual treatment of the localized disease is surgery with or without radiotherapy. No standard treatment for metastatic disease although some case reports had reported the effectiveness of programmed cell death protein 1 (PD-1) blockade as a possible treatment.
What does spindle cell melanoma look like?
Features of spindle cell melanoma under microscopy include: An abundance of spindle-shaped tumour cells (> 90% of a tumour) Uniform, wavy, and slender nuclei, with variable size and shapes (pleomorphism) and variable nuclear atypia (abnormal appearance of cell nuclei)
How long can you live with spindle cell sarcoma?
5-year relative survival rates for soft tissue sarcoma
| SEER Stage | 5-Year Relative Survival Rate |
|---|---|
| Localized | 81% |
| Regional | 56% |
| Distant | 15% |
| All SEER stages combined | 65% |
How aggressive is spindle cell carcinoma?
Spindle cell carcinoma (SpCC) is an uncommon aggressive biphasic malignancy that has the propensity to manifest itself in the upper aerodigestive tract, including the oral mucosa.
Does spindle cell carcinoma spread?
As with all cancers, spindle cell sarcoma can spread (metastasise) to other parts of the body.
Is melanoma a spindle cell tumor?
Spindle cell melanoma (SCM) is a rare subtype of malignant melanoma composed of spindled neoplastic cells arranged in sheets and fascicles (1). The diagnosis of SCM is challenging, as SCM may occur anywhere on the body and frequently mimics amelanotic lesions, including scarring and inflammation (2–4).
Is sarcoma worse than carcinoma?
It’s very hard to say whether carcinomas or sarcomas are more dangerous. Survival rates for any type of cancer depend on a variety of factors, including: size of the tumor. location of the tumor.
What causes spindle cell carcinoma?
Siegel says the cause of spindle cell sarcoma is unknown. There is a genetic predisposition; however, it is not commonly thought to be hereditary. Some rare, inherited genetic conditions are considered risk factors for soft-tissue sarcoma.
How common is spindle cell sarcoma?
Spindle cell sarcoma is an extremely rare bone cancer. It makes up only 2-5% of all types of bone cancer and typically presents in people over 40 years of age. Spindle cell sarcoma is a soft tissue tumor usually found in the arm or leg bones, or in the pelvis.