Does a molar pregnancy cause hypothyroidism?
Molecular variants of hCG found in molar pregnancies have increased thyrotropic potency (7). When gestational trophoblastic disease causes a significant rise in hCG levels, it may induce hyperthyroidism that requires treatment. As expected, thyrotoxicosis resolves with treatment of GTD and normalization of hCG levels.
How does a molar pregnancy affect the thyroid?
Since hCG and TSH receptors are similar, hCG acts directly on the TSH receptors that are present in the thyroid resulting in an increased level of thyroid hormones T3 and T4 and decreased TSH levels . The first reported case of hyperthyroidism as a complication of hydatidiform mole was in 1955 .
Does pregnancy cause thyroid storm?
Thyroid storm, a rare condition affecting 1 percent of pregnant women with hyperthyroidism, is characterized by severe, acute exacerbation of the signs and symptoms of hyperthyroidism.
What is the most common complication of molar pregnancy?
Complications of molar pregnancy haemorrhage. ovarian cysts. breathlessness (when it spreads to the lungs) pre-eclampsia (toxaemia of pregnancy), involving high levels of certain substances in the blood that raise blood pressure and affect the kidneys and (sometimes) liver function.
Does hCG affect thyroid levels?
hCG can bind to the TSH receptors present in thyroid tissue and act like a weak form of TSH to cause the thyroid to produce and release more thyroxine and triiodothyronine. hCG is the hormone measured in the pregnancy tests.
Can pregnancy trigger Graves disease?
Pregnancy affects the thyroid gland. The risk of developing Graves’ disease is seven times higher in the year after giving birth. This suggests that pregnancy might trigger or reveal Graves’ disease in some women.
How long after a molar pregnancy Can you try again?
The risk of having another molar pregnancy is small (about 1 in 80). It’s best not to try getting pregnant again until all your follow-up treatment has finished. For most women, this will take about 6 months. If you have GTN, you will need to wait for 12 months after you have finished chemotherapy treatment.
Why does hydatidiform mole cause hyperthyroidism?
Gestational trophoblastic disease (GTD) which includes hydatidiform mole, invasive mole, placental site trophoblastic tumor, and choriocarcinoma is a rare cause of hyperthyroidism due to excess production of placental human chorionic gonadotrophin hormone (hCG) by tumor cells.
Can hCG cause hyperthyroidism?
Human chorionic gonadotropin (HCG)–induced hyperthyroidism is a rare cause of hyperthyroidism. It is seen in patients suffering from conditions associated with extremely high levels of HCG, such as hyperemesis gravidarum, hydatidiform moles, and germ cell tumors.
Why did I have a molar pregnancy?
Molar pregnancies are caused by an imbalance in genetic material (chromosomes) in the pregnancy. This usually occurs when an egg that contains no genetic information is fertilised by a sperm (a complete molar pregnancy), or when a normal egg is fertilised by two sperm (a partial molar pregnancy).
Can beta hCG cause hyperthyroidism?
The alpha subunit of HCG and TSH are homologous, so β-HCG can cross-react with the TSH receptors and induce hyperthyroidism. High level of β-HCG serum can lead to hyperthyroidism, which can aggravate the patient’s malignant manifestations.
Can hCG cause thyroid nodules?
In conclusion, hCG has thyroid-stimulating activity that influences thyroid function early in pregnancy when hCG levels are high. Excessive hCG secretion may cause hyperthyroidism in patients with hyperemesis gravidarum or trophoblastic tumors.
What percent of molar pregnancies are cancerous?
Hye Sook Chon, a gynecological oncologist at Moffitt Cancer Center, says 15% to20% of women who experience a complete molar pregnancy, or mole, develop GTN.