What is the 21-gene recurrence score?
The 21-gene recurrence score (RS) assay (Oncotype DX; Genomic Health, Redwood City, CA, USA) is used to assess the breast-cancer genes related to proliferation and invasion. The 21-gene RS assay can also provide information on the risk of distant recurrence as well as the benefit of adjuvant chemotherapy (11–13).
What is a good Oncotype score?
A score of 15 or smaller means you have a low risk of the cancer returning if you get hormone treatment. You probably will not benefit from receiving chemotherapy. A score between 16 and 20 means you have a low to medium risk of the cancer returning if you get hormone treatment.
What is Oncotype recurrence score?
Recurrence Score result This number, between 0 and 100, is calculated by measuring the activity of specific genes in the breast cancer tissue. The Recurrence Score® result is used to predict the risk of the breast cancer returning at a distant site and whether chemotherapy may help reduce the risk.
How do you read an Oncotype report?
- Recurrence Score of 0-15: The cancer has a low risk of recurrence.
- Recurrence Score of 16-20: The cancer has a low to medium risk of recurrence.
- Recurrence Score of 21-25: The cancer has a medium risk of recurrence.
- Recurrence Score of 26-100: The cancer has a high risk of recurrence.
What are the 21 genes in Oncotype DX?
Table 2
| Oncotype DX 21 genes | Prosigna/PAM50 50 genes | |
|---|---|---|
| Oncotype DX | BIRC5, CCNB1, MYBL2, MMP11, GRB7, ESR1, PGR, BCL, BAG1 | |
| MammaPrint | – | KNTC2, MELK, ORC6L |
| Prosigna/PAM50 | – | |
| EndoPredict | – | – |
What are the 21 genes in Oncotype?
How accurate is the Oncotype test?
21-gene RS accurately predicted 97% of the low RS stratified patients to avoid receiving chemotherapy. However, addition of chemotherapy in the treatment regimen for node positive, Her-2/neu positive, high Ki-67, and PR negative tumors may be beneficial regardless of 21-gene RS.
How do I read my Oncotype score?
How reliable is the Oncotype DX test?
“Consistent with results from the NSABP and SWOG clinical validation studies of Oncotype DX, the new multiple prospective outcomes studies provide additional strong evidence of the test’s ability to accurately predict prospective outcomes regardless of age, tumour size and grade,” said Norman Wolmark, M.D., chairman of …
Can you have a lumpectomy twice?
Sometimes after the pathology report is done, the margins are found to contain cancer cells and more surgery is needed. This additional surgery is called a re-excision lumpectomy. Because all the breast tissue is removed during a mastectomy, there’s usually no need for more surgery.
What are the chances of invasive ductal carcinoma returning?
The local recurrence rate was zero of 44 for patients with ductal carcinoma in situ and 5.6 percent (10 of 177) for patients with invasive carcinoma during a mean follow-up period of 9.8 years. There was a 6.8 percent (12 of 177) metastatic recurrence rate in the invasive carcinoma group.
How common is re-excision after lumpectomy?
Results: For 6,725 patients undergoing initial lumpectomy for cancer, 328 surgeons reported 1,451 (21.6 %) patients had one or more re-excisions. The most common reasons for re-excision were ink positive margins in 783 (49.7 %), margin <1 mm (34.3 %), and margin 1-2 mm (7.2 %).