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Does chemo affect your liver?

Does chemo affect your liver?

Conditions such as sinusoidal obstructive syndrome, steatosis, and pseudocirrhosis are more commonly associated with chemotherapy. These conditions can display clinical signs of acute hepatitis, liver cirrhosis, and even liver failure.

What does it mean if MPV is high in blood test?

A high MPV means that your platelets are larger than average. This is sometimes a sign that you’re producing too many platelets. Platelets are produced in the bone marrow and released into the bloodstream. Larger platelets are usually young and more recently released from the bone marrow.

What is MPV dog blood test?

Mean platelet volume (MPV) and plateletcrit (PCT) are indices used in evaluating immune‐mediated thrombocytopenia (IMT) in humans and in dogs with congenital macrothrombocytopenia. These indices may provide clinically valuable information in acquired thrombocytopenia.

Can chemo damage liver be reversed?

Chemotherapy-induced liver damage in patients with cancer may occur during chemotherapy or after the total course. Although liver function impairment may be reversed in some patients after treatment, abnormal liver function may lead to an interruption of anti-tumor therapy and jeopardize the prognosis of patients [20].

What cancers cause low MPV?

Many research studies found that MPV changed in gastric cancer, ovarian cancer, lung cancer, colon cancer, and breast cancer (Gu et al., 2015; Kemalet al., 2014; Kilincalp et al., 2014; Kumagai et al., 2015; Li et al., 2014).

What is normal MPV for dog?

Of domestic animal species, cats had the highest MPVs (mean 11 fL), followed by dogs (mean 7.2 fL), horses (mean 5.0 fL), cattle (mean 4.8 fL), and goats (mean 4.2 fL) when blood was collected with sodium citrate and assayed using the same automated analyzer (Series 810, Baker Instruments Corp., Allentown, PA).

Can chemo cause permanent liver damage?

High-dose chemotherapy and total body irradiation given to prepare for a stem cell transplant can cause liver damage. Chronic graft-versus-host disease (GVHD) or veno-occlusive disease (VOD) of the liver that develops after a stem cell transplant can also cause liver damage.

Does high MPV mean inflammation?

The MPV has been shown to correlate with the function and activation of platelets [9–11]. The importance of MPV has been emphasized as an inflammation marker in some chronic inflammatory disorders, such as inflammatory intestinal diseases, rheumatoid arthritis, and ankylosing spondylitis.

Why did my MPV go down?

A low MPV can indicate exposure to certain drugs that are harmful to cells. It may also indicate marrow hypoplasia, a disorder that causes a decrease in blood cell production. To learn what your results mean, talk to your health care provider.

What diseases are associated with a low MPV?

Conditions that may be associated with a low MPV and variable platelet counts include:

  • Bone marrow failure.
  • Lupus.
  • Splenomegaly (enlargement of the spleen), which often causes platelets to be trapped in the spleen.
  • Medications that suppress platelet formation, such as chemotherapy.
  • Hypothyroidism.
  • Iron deficiency anemia.

What meds can cause low MPV?

Some prescribed medications can also cause thrombocytopenia, including:

  • amiodarone.
  • ampicillin and other antibiotics.
  • cimetidine.
  • piperacillin.
  • seizure medications, such as carbamazepine.
  • sulfonamides, such as trimethoprim-sulfamethoxazole.
  • vancomycin.

Can a dog recover from low platelets?

The prognosis for ITP ranges from good to guarded. Although almost 80 percent of dogs with this disorder will recover, that means that another 20 percent are either euthanized or die because of the disease.

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