What is the drug Prandin used for?
It is used in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. It works by stimulating the body to produce more insulin.
What are the side effects of repaglinide?
Incidence not known
- Back, leg, or stomach pains.
- blistering, peeling, or loosening of the skin.
- darkened urine.
- difficulty with breathing.
- general body swelling.
- general tiredness and weakness.
- indigestion.
- itching or rash.
Is insulin a repaglinide?
Repaglinide is an insulin secretatogue with a rapid onset and relatively short duration of action (1–3) that was developed for prandial glucose regulation.
What type of drug is repaglinide?
Repaglinide is a drug used in the treatment of diabetes mellitus type 2. It belongs to a class of antihyperglycemic agents known as meglitinides, along with nateglinide.
Why was Prandin discontinued?
Over one year, 13% of PRANDIN patients were discontinued due to adverse reactions. The most common adverse reactions leading to withdrawal were hyperglycemia, hypoglycemia, and related symptoms. Table 1 lists the common adverse reactions for PRANDIN patients compared to placebo in trials 12 to 24 weeks duration.
What is the difference between metformin and repaglinide?
Repaglinide causes your pancreas to release more insulin into the blood stream. Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better.
Is repaglinide better than metformin?
Various studies have demonstrated that both metformin and repaglinide have equal efficacy in maintaining blood glucose levels and cardiovascular risk profile in patients with type 2 diabetes mellitus [12,13].
Is repaglinide the same as metformin?
Does repaglinide contain metformin?
PrandiMet (repaglinide and metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: repaglinide and metformin HCl.
Is Prandin still available?
All of the above formulations have been discontinued. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication. See also: Generic Drug FAQ.
Is repaglinide a safe drug?
Many people using this medication do not have serious side effects. Repaglinide can cause low blood sugar (hypoglycemia) especially if you are taking other medicines for diabetes.
Can you take repaglinide and metformin together?
Adults—The dose should be individualized starting at 1 milligram (mg) repaglinide and 500 mg metformin combination 2 times a day. Your doctor may increase your dose as needed to control your blood sugar up to a maximum of 10 mg repaglinide and 2500 mg metformin combination per day, divided into 2 or 3 doses.
How much does repaglinide lower A1C?
Studies examining the use of repaglinide as monotherapy have shown A1C reductions up to 2.3% with fasting and postprandial reductions of 3.9 mmol/L and 6.4 mmol/L respectively.
When should I take repaglinide?
This medicine is usually taken within 15 minutes before a meal but may be taken up to 30 minutes before a meal. If you skip a meal, you should skip your dose for that meal.
Which is better metformin or repaglinide?
We showed that both metformin and repaglinide significantly decreased fasting blood glucose and HbA1c in newly diagnosed type 2 diabetes. The anti-diabetic effect of repaglinide was greater than metformin.
Why is repaglinide not used?
Repaglinide works by causing your pancreas to release more insulin into the blood stream. This medicine does not help patients who have insulin-dependent or type 1 diabetes. This medicine is available only with your doctor’s prescription.
When is the best time to take repaglinide?
This medicine usually is taken 15 minutes before a meal but may be taken up to 30 minutes before a meal.