What is Mrfit trial?
MRFIT was a randomized, primary prevention trial, conducted at 22 US clinical centers from 1973 to 1982 to test whether lowering elevated serum cholesterol and diastolic blood pressure and ceasing cigarette smoking would reduce coronary heart disease mortality.
What type of study is MRFIT?
Interventional
Multiple Risk Factor Intervention Trial for the Prevention of Coronary Heart Disease (MRFIT)
| Study Type : | Interventional (Clinical Trial) |
| Allocation: | Randomized |
| Primary Purpose: | Prevention |
| Study Start Date : | June 1972 |
| Study Completion Date : | July 1998 |
What does MRFIT stand for?
The Multiple Risk Factor Intervention Trial (MRFIT) was a seminal clinical trial in CHD risk prevention that randomized 12,866 men between 35 to 57 years old with high risk of death from CHD to receive a multi-factor “special intervention” (SI) program or usual medical care.
What is a multiple risk intervention?
In hypertensive patients at high risk for coronary artery disease, multiple risk factor reduction interventions reduce risk factors and mortality. In other patients, multiple risk factor reduction interventions reduce total cholesterol levels, blood pressure (systolic and diastolic) levels, and smoking rates.
What was the main objective of the Multiple Risk Factor Intervention Trial What was the main finding?
The main finding of our report was that the relationship between serum cholesterol and CHD mortality is continuous, graded, and strong; ie, CHD risk is progressively higher at every cholesterol level from 160 mg/dL and higher levels, with no threshold.
When did the Framingham study begin?
1948
When it launched in 1948 the original goal of the Framingham Heart Study (FHS) was to identify common factors or characteristics that contribute to cardiovascular disease.
What is multiple risk factor reduction?
What was the main objective of the Multiple risk factor intervention trial What was the main finding?
Why is the Framingham study important?
FHS findings have informed the understanding of how cardiovascular health affects the rest of the body. The study found high blood pressure and high blood cholesterol to be major risk factors for cardiovascular disease.
What data collection methods were used in the Framingham Heart Study?
Longitudinal measures of subclinical disease gathered through serial carotid ultrasounds, echocardiography, arterial tonometry and CT and MR imaging of cardiac structure, central arterial and coronary atherosclerosis.
What does risk factor mean?
something that increases risk
Definition of risk factor : something that increases risk or susceptibility.
What were the three risk factors discovered in the Framingham study?
THE FRAMINGHAM HEART STUDY Much of our appreciation of the pathophysiology of heart disease came from the results of studies from the FHS. It established the traditional risk factors, such as high blood pressure, diabetes, and cigarette smoking for coronary heart disease.
What are the limitations of the Framingham Heart Study?
Limitations. The Framingham Risk Score predicts only future coronary heart disease (CHD) events, however, it does not predict future total cardiovascular events, meaning that it does not predict risk for stroke, transient ischemic attack (TIA), and heart failure.
What are the 6 health risk factors?
3.2, health risk factors and their main parameters in built environments are further identified and classified into six groups: biological, chemical, physical, psychosocial, personal, and others.
What type of study is Framingham Heart Study?
Framingham is a longitudinal cohort study, a type of epidemiological study that follows a group of individuals over time to determine the natural history of certain diseases, explore the behavior of those diseases, and identify the factors that might explain their development.
What did the Framingham study conclude?
The study found high blood pressure and high blood cholesterol to be major risk factors for cardiovascular disease.
Why was the Framingham study so important?
It established the traditional risk factors, such as high blood pressure, diabetes, and cigarette smoking for coronary heart disease. Framingham also spearheaded the study of chronic noninfectious diseases in the USA and introduced preventive medicine.
What type of study is the Framingham Heart Study?