How do you calculate cisplatin?
The actually utilized dose (AD) of cisplatin was calculated using the following formula: AD (mg) = total dose (TD) (mg)-losing dose (LD) (mg); LD = volume (ml) of the perfusate (VPretained) that was retained in the HIPEC treatment system at the end of HIPEC * concentration of cisplatin in the perfusate (mg/ml).
How do you make cisplatin solution?
A cisplatin solution in a concentration of 0.1 mg/ml was also analysed. The solution was prepared by adding a concentrate of 1 mg/ml to a 0.9% NaCl solution and storing at the temperature of 21.7 ±1.3°C without access to light.
What is the strength of cisplatin injection?
Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose vials, each mL containing 1 mg of cisplatin (cisplatin injection) and 9 mg sodium chloride in water for injection.
How fast can you infuse cisplatin?
The cisplatin solution for infusion prepared according to instructions (see section 6.6.) should be administered by intravenous infusion over a period of 6 to 8 hours.
How are chemotherapy drug doses calculated?
Dosage calculations for the majority of cytotoxic chemotherapeutic cancer drugs are based on the body surface area (BSA) of the patient, where the dosage is reported in milligrams, grams, or units per square meter of BSA. It is calculated for any cancer drug where the dose is based on BSA.
How is chemo measured?
Most chemo drugs are measured in milligrams (mg). The overall dose may be based on a person’s body weight in kilograms (1 kilogram is 2.2 pounds).
How do you dissolve cisplatin in water?
You can dissolve cisplatin in deionized water by vortexing it real well, but do not go higher than 2.5 mM, which is the limit. Before use, let the solution into a shaker for 10 min at RT.
How do you dissolve saline cisplatin?
In the clinic, cisplatin is typically provided as a lyophilized powder in a vial containing 50 mg cisplatin, 450 mg NaCl and 500 mg mannitol. When dissolved in 50 mL of water, this results in a 1 mg/mL solution (3.3 mM) of cisplatin dissolved in 150 mM saline.
How do you inject cisplatin?
Cisplatin injection comes as a solution (liquid) to be injected over 6 to 8 hours intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given once every 3 to 4 weeks.
How long is cisplatin given?
Your course of chemotherapy Each cycle of cisplatin usually takes 21 days (3 weeks). You usually have the cisplatin on the first day of each cycle. But this will depend on the type of cancer you have. Your doctor or nurse will discuss your treatment plan with you.
Why is cisplatin not given orally?
Cisplatin is administered through a vein (intravenously or IV) as an infusion. There is no pill form of cisplatin. Cisplatin is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given.
How do you calculate chemo m2?
References
- Equation: BSA (m2) = 0.0235 x Height(cm)0.42246 x Weight(kg)0.51456
- Equation: BSA (m2) = 0.024265 x Height(cm)0.3964 x Weight(kg)0.5378
- Equation: BSA (m2) = SQR RT ( [Height(cm) x Weight(kg) ]/ 3600 )
Can cisplatin be refrigerated?
Storage: Cisplatin Injection is a sterile, multidose vial without preservatives. Store at 15° to 25°C (59° to 77°F). Do not refrigerate.
Can cisplatin be dissolved in PBS?
Clinical formulation was employed for in vitro experiments in 11 – 23% of papers. However, in some studies cisplatin was dissolved in PBS (chloride concentration 140 mM – phosphate has been reported to not appreciably alter cisplatin aquation (25)) or saline (chloride concentration 154 mM).
Why is cisplatin given intravenously?
Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or testicles. Cisplatin is an antineoplastic agent (cancer medicine). It interferes with the growth of cancer cells, which are eventually destroyed by the body.