How does MIBG therapy work?
I-131 MIBG is administered to a child through an intravenous line and absorbed by tumor cells, which are killed by radiation emitted by the radioactive I-131. This therapy destroys tumors while sparing normal, healthy tissue.
How long does MIBG therapy take?
The procedure used to put the MIBG inside your child’s body is called an infusion, and it takes less than 2 hours.
What should I avoid before MIBG scan?
What should I avoid before an MIBG scan?
- ACE inhibitors.
- Allergy and cold medications.
- Amiodarone for arrhythmia.
- Antidepressants.
- Calcium channel blockers.
- Opioids.
Is MIBG FDA approved?
HSA-I-131-MIBG was approved by the US Food and Drug Administration (FDA) for the treatment of patients with MIBG-avid MPPGs in 2018. As the only FDA-approved therapy for patients with MPPGs, HSA-I-131-MIBG is considered the standard of care in the US for patients with MIBG-avid tumors.
Is MIBG an immunotherapy?
Clinical trials using I-131 MIBG treatment The immunotherapy consists of an antibody that attaches to neuroblastoma cells and a drug that helps your child’s immune system work better.
What is I 131 MIBG used for?
I-131-MIBG therapy is a type of radiation therapy used to kill cancer cells in children with certain kinds of cancer. It’s a way to get radiation inside your child’s body to target cancer cells wherever they are. The medicine is a clear fluid that looks like water.
What is MIBG?
MIBG, called meta-iodobenzylguanidine, is a chemical that started as a blood pressure medicine. It was found to be preferentially picked up by neural crest cells which give rise to, among other things, parts of your adrenal glands. Neural crest cells can also give rise to a type of cancer called neuroblastoma.
How much does MIBG therapy cost?
This is expensive (US $8000–16,000 per year), and treatment may be for many years.